U.S. Department of Health &
Human Services
OFFICE OF CLINICAL RESEARCH EDUCATION AND COLLABORATION OUTREACH
Overview
Programs
Resources
Staff
Bench-to-Bedside and Back Program (BtB)
2006 Bench-to-Bedside and Back Program (BtB) Funded Projects
NIH expands Initiative to Encourage Bench-to-Bedside Research
In 2006, the BtB awarded nearly $4 million to fund projects. This marked the first awards given for teams made up of NIH intramural and extramural collaborators.
Also in 2006, projects in minority health and health disparities and women's health were specifically funded for the first time.
AIDS CATEGORY:
| Project | Institute or institution/Investigators |
|---|---|
| The effect of HIV-1 Infection on Endogenous miRNA Expression in vivo | NIAID: Jeang, Kuan-Teh St. Michael's Medical Center: Smith, Stephen |
| Genetic Characteristics of HIV-1 During Suppressive Antiretroviral Therapy | NCI: Maldarelli, Frank; Coffin, John; Palmer, Sarah;
Weigand, Ann; Kearney, Mary Johns Hopkins University: Persaud, Deborah NIAID: Kottilil, Shyamasundaran |
| Evaluation of Molecular Methods for the non-invasive Diagnosis of Pneumocystis and Tuberculosis and Molecular Evaluation of Non-subtype B HIV Quasispecies in the Lung | CC: Kovacs, Joseph; Fischer, Steven
NCI: Maldarelli, Frank University of California, San Francisco: Huang, Laurence San Francisco General Hospital: Davis, J. Lucian SAIC: Imamichi, Hiromi Makerere University, Mulago Hospital: Worodria, William; Yoo, Samuel |
| Microalbuminuria and Podocyturia in Patients with HIV disease: Detection, Characterization, and Therapy | NIDDK: Kopp, Jeffrey; Howard, Lilian Children's National Medical Center: McBryde, Kevin |
RARE DISEASES CATEGORY:
| Institute(s) | Project |
|---|---|
| Role of Cyclin D1 in Myelodysplasia | NHLBI: Sloand, Elaine; Young, Neal; Scheinberg, Phillip;
Barrett John CC: Kurlander Roger Harvard University: Groopman Jerome Georgetown University: Blancato Jan National Naval Medical Center: More, Kenneth Salisbury District Hospital (UK): Crolla, John |
| Exploring the Anti-Tumor Effects of in vitro Expanded Natural Killer (NK) Cells Against Renal Cell Carcinoma Sensitized to NK-TRAIL Cytotoxicity with Bortezomib | NHLBI: Childs, Richard; Lundqvist, Andreas CC: Read, E.J.; Suffredini, Anthony Walter Reed Army Medical Center: Gorak, Edward; Alvarez, Gauri |
| A New Global Function for a Rare Disease Gene: Clinical Significance of the Regulation of Mitochondrial Respiration by Tumor Suppressor p53 in Li-Fraumeni Syndrome | NHLBI: Hwang, Paul MD Anderson Cancer Center: Strong, Louise; Khakoo, Aarif; Arena, Ross |
| Therapeutic Approaches for Cancer Stem Cells in Small Cell Neuroendocrine Carcinomas | NCI: Harris, Curtis; Varticovski, Lyuba; Dennis, Phillip
A.; Bates, Susan NHLBI: Dunbar, Cynthia NINDS: McKay, Ron Memorial Sloan-Kettering Cancer Center: Travis, William D. |
| High Density Genotyping in Diffuse Large B-cell Lymphoma (DLBCL) and Follicular Lymphoma - Translating Etiologic Clues into Prognostic Relevance Within the NCI-SEER NHL Case Control Study | NCI: Chanock, Stephen; Wang, Sophia; Hartge, Patricia;
Staudt, Lou; Morton, Lindsay; Wacholder, Sholom; Rothman, Nathaniel Mayo Clinic College of Medicine: Cerhan, James University of Southern California: Cozen, Wendy Fred Hutchinson Cancer Research Center: Davis, Scott; Karmanos Cancer Center & Wayne State University: Severson, Richard |
| Novel Suicide Gene-Modified Donor Th2 Cells for GVHD Prevention | CC: Reed, Elizabeth J.; Carter, Charles NCI: Fowler, Daniel University of Toronto/Ontario Cancer Institute: Medin, Jeffrey University of Illinois: Lavie, Arnon |
| A Nutrigenomics Intervention for the Study of the Role of Dietary Sitosterol on Lipid, Glucose and Energy Metabolism | NIDDK: Celi, Francesco NHLBI: Sachdev, Vandana University of Maryland: Horenstein, Richard; Fried, Susan; Shuldiner, Alan |
| Pilot Trial of Intravenous Nitrite for Sickle Cell Vaso-Occlusive Pain Crisis | NHLBI: Gladwin, Mark; Machado, Roberto; Taylor, James;
Wang, Xunde CC: Kato, Gregory NIDDK: Schechter, Alan; Shiva, Sruti NCI: Mack, Kyle Drexel University: Hsu, Lewis |
MINORITY HEALTH AND HEALTH DISPARITIES:
| Project | Institute or institution/Investigators |
|---|---|
| Hemolysis, HIV/AIDS and Parasitic Infections Associated Secondary Pulmonary Arterial Hypertension in Sickle Cell Diseases | NHLBI: Aliyi, Zakari; Gladwin, Mark; Taylor, James, G.;
Machado, Roberto CC: Cato, Gregory NIDDK: Rogers, Griffin |
| Novel Bench-to-Bedside Research Methods for Drug Addiction: Development, Validation and Application | NIDA: Stein, Elliott University of Pennsylvania: Childress, Anna Rose; Peoples, Laura |
| Breast Cancer among African American Women: The role of Missense Changes in the BRCA1 and BRCA2 Breast Cancer Susceptibility Genes Using a Population-Based Approach | NHGRI: Ostrander, Elaine Fred Hutchinson Cancer Research Institute: Malone, Kathleen |
| Melanocortin 3 receptor Mutations as an Etiology for Obesity in African American and Caucasian children | NICHD: Yanovski, Jack; Ning, Cong; Koo, Ja-Shin;
Westphal, Heiner J. NIDDK: Gavrilova, Oksana University of Wisconsin: Schoeller, Dale |
WOMEN'S HEALTH
| Project | Institute or institution/Investigators |
|---|---|
| Vitamin E Pharmacokinetics and Oxidative Biomarkers in Normal and Obese Women | NIDDK: Levine, Mark Oregon State University: Traber, Maret |
CO-FUNDED (INSTITUTE AND NCRR)
| Project | Institute or institution/Investigators |
|---|---|
| Immunosuppression Minimization by Biological Response Monitoring | NIDDK: Kirk, Allen Washington Hospital Center: Light, Jimmy |
| A Preliminary Assessment of the use of Ocular Coherence Tomography and Magnetic Resonance Imaging as Outcome Measures for Studying the Optic Nerve in Studies of Neuroprotection in Multiple Sclerosis | NINDS: McFarland, Henry NEI: Nussenblatt, Robert Johns Hopkins School of Medicine: Calabresi, Peter University of Pennsylvania: Balcer, Laura |
Social Media Links