AIDS (Support from Office of AIDS Research (OAR)) Exemplary HIV/AIDS projects aligned with the overarching HIV/AIDS research priorities will be considered for funding (https://www.oar.nih.gov/hiv-policy-and-research/research-priorities).

Health Disparities & Minority Health (Support from the National Institute on Minority Health & Health Disparities): NIMHD will fund projects that support the overall NIH effort to reduce and ultimately eliminate health disparities, improve minority health, and optimize health for all. Research projects must focus on 1) improving our understanding of ways to reduce health disparities among persons of less privileged socioeconomic status, underserved rural residents, or racial and/or ethnic minority populations; or 2) health determinants and mechanisms of health outcomes in racial and/or ethnic minority populations as defined by the US Census.

Behavioral and Social Sciences (Support from the NIH Office of Behavioral and Social Sciences Research): OBSSR will consider funding projects that facilitate the translation of research findings into effective interventions to prevent or treat disease with the aim of promoting and optimizing health. The work must incorporate basic or applied behavioral or social sciences (BSS) theory, research, principles, or strategies. Of particular interest are interdisciplinary research projects on factors that influence prevention and health outcomes. Research in which scientists and practitioners work together to accelerate the translation, implementation, dissemination of BSS research findings or that employ BSS theory or principles or evaluate BSS strategies or components are of high priority to OBSSR. The Office has strong interests in the development of behavioral interventions for prevention and health improvement, including studies in the areas of gene-environment interactions, adherence (at the patient and provider levels), behavior change and maintenance, measurement harmonization, areas of and causes of health outcome disparities, primary care, mobile health, and shared medical decision-making, among other areas.

Dietary Supplements (Support from the Office of Dietary Supplements): Awards in this funding category are designed to promote scientific study of the benefits of dietary supplements in maintaining health and preventing chronic disease and other health-related conditions but not in disease treatment. In the U.S., dietary supplement ingredients are usually defined as including vitamins, minerals, amino acids, and herbs or other botanicals, that are intended to be taken by mouth and are consumed in addition to the regular diet.

Rare Diseases (Support from Office of Rare Diseases Research in the National Center for Advancing Translational Sciences): ORDR/NCATS will provide funding in this category. Projects must focus on an area of science/research directly related to a rare disease. An orphan or rare disease is generally considered to have a prevalence of less than 200,000 affected individuals in the United States. Diseases with a prevalence of more than 200,000 affected individuals may be included if a biologically plausible subset of the disease, with a prevalence less than 200,000, can be scientifically justified for focused research. A comprehensive list of rare diseases, updated regularly, is available at https://rarediseases.info.nih.gov/search-result.

Please note: All applications in this category will be considered for funding in the OCRECO research BtB Funds.

Office of Research on Women’s Health (Support from the Office of Research on Women’s Health (ORWH)): Applications seeking funding from ORWH should focus on efforts to improve the health of women through biomedical and behavioral research, and ensure that the proposed work is aligned with at least one goal and objective outlined in the NIH-Wide Strategic Plan for Research on the Health of Women 2024-2028 (https://www.nih.gov/women/strategicplan). Broadly defined, women’s health includes female specific conditions (e.g., endometriosis, gynecologic cancers, menopause), conditions that disproportionately affect women (e.g., mental health conditions, migraine), and conditions that present and progress differently in women (e.g., cardiovascular disease, HIV). The influence of sex as a biological variable on health and disease is of particular interest. The Office of Autoimmune Disease Research in the Office of Research on Women’s Health (OADR-ORWH) is seeking applications to support bench-to-bedside research in autoimmune disease. The portfolio of the Office of Autoimmune Disease research encompasses more than 140 diseases and conditions and encompasses basic and translational science and is seeking applications that focus on either autoimmune aspects of the specific disease or diseases being studied, and/or autoimmunity pathogenesis in more general terms. This may include studies investigating basic immunology, gene expression, pathophysiology, diagnostic imaging, environmental exposures, biomarkers, sex influences, co-occurring autoimmune diseases, mechanistic pathways as therapeutic targets, animal models, systems biology, health outcomes research, symptom science, and translational research as they related to autoimmune disease and conditions.

All projects that are not funded by the Donor Offices as well as additional meritorious projects that don't fall within the scope of the categories listed above will be considered for funding in the "general" category. These projects are funded using Office of Clinical Research Education and Collaboration Outreach (OCRECO) BtB Funds provided by the NIH Director.

Individual IC and Deputy Director for Intramural Research (DDIR)

Occasionally some ICs and the DDIR will provide funds for highly scored projects that did not fit in donor offices and involve intramural collaborators only. Our program staff will assist you in approaching the appropriate IC or the DDIR for funding support.

Cancer Moonshot Funds-NCI Administrative Supplements (2021 Cycle ONLY)

For additional details please check the 2021 Call for proposals .