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OFFICE OF CLINICAL RESEARCH EDUCATION AND COLLABORATION OUTREACH

Opportunities for Collaborative Research at the Clinical Center (U01)

Awarded Project or Grants

FY2023 Awards

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Grant No. 1 U01 HD107957 01A1 PI: SOBREIRA, NARA
Title: Delineation of the natural history of Ollier disease and Muffucci syndrome and investigation of their genetic bases

National Cancer Institute (NCI)

Grant No. 1 U01 CA268808 01A1 PI: BAGCI, ULAS
Title: Hybrid Intelligence for Trustable Diagnosis And Patient Management of Prostate Cancer (HIT-PIRADS)

Grant No. 1 U01 CA278474 01 PI: CLAPP, DAVID W
Title: Preclinical-clinical trials collaboration to effectively advance new combination therapies for atypical neurofibroma in neurofibromatosis type 1

Grant No. 1 U01 CA268810 01A1 PI: KIBEL, ADAM S
Title: Polygenic risk stratification combined with mpMRI to identify clinically relevant prostate cancer

National Heart, Lung and Blood (NHLBI)

Grant No. 1 U01 HL167613 01 PI: NAYAK, KRISHNA S
Title: Volumetric Real-Time MRI at 0.55 Tesla

FY2022 Awards
National Cancer Institute (NCI)

Grant No. 1 U01 CA268813 01 PI: CHANG, JENNY C-N
Title: A phase II multi-center trial evaluating dual targeting of the PI3K/AKT and NOS pathways for treating metaplastic breast cancer (MpBC)

Grant No. 1 U01 CA268814 01 PI: CICHOWSKI, KAREN M
Title: Preclinical-Clinical Trials Collaboration to effectively advance new combination therapies for malignant peripheral nerve sheath tumors

Grant No. 1 U01 CA257666 01A1 PI: GODLEY, LUCY ANN
Title: The role of inflammation in driving leukemogenesis in germline predisposition syndromes

Grant No. 1 U01 CA268933 01 PI: TONER, MEHMET
Title: Microfluidic isolation and molecular analysis of circulating tumor cells for the study of neuroendocrine transdifferentiation in prostate cancer

Grant No. 1 U01 CA268806 01 PI: ZAROUR, HASSANE M
Title: Therapy with fecal microbiota transplantation and immune checkpoint blockade for solid tumors

National Heart, Lung and Blood (NHLBI)

Grant No. 1 U01 HL156655 01A1 PI: BOUCHER, RICHARD CHARLES
Title: The molecular and cellular mechanisms of the STAT3 mutation-mediated pulmonary disorder in Autosomal Dominant Hyper IgE Syndrome (AD-HIES)

National Institute of Dental and Craniofacial Research (NIDCR)

Grant No. 1 U01 DE031512 01 PI: YAO, HAI
Title: ATTRACT: Assessment of Temporomandibular JoinT MoRphology, Mechanics, And Mechanobiology in Class II and III Target and Surgical Phenotypes


FY2021 Awards
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Grant No. 1 U01 HD104482 01 PI: SPENCER, THOMAS E
Title: Endometrial Basis for Infertility in Women with Recurrent Implantation Failure and Pregnancy Loss

National Cancer Institute (NCI)

Grant No. 1 U01 CA257638 01 PI: SPRATT, DANIEL EIDELBERG
Title: Quantifying and Personalizing the Clinical Benefit of Metastasis-Directed Therapy in Men with De Novo Oligometastatic Prostate Cancer

National Eye Institute (NEI)

Grant No. 1 U01 EY032403 01 PI: LUPO, PHILIP J
Title: Microphthalmia, Anophthalmia, and Coloboma Genetic Epidemiology in Children (MAGIC) Study

National Heart, Lung and Blood (NHLBI)

Grant No. 1 U01 HL156620 01 PI: DEBAUN, MICHAEL R
Title: Clinical and genetic risk factors associated with adverse long-term health outcomes after curative therapies in individuals with sickle cell disease

Grant No. 1 U01 HL151203 01A1 PI: IRUELA-ARISPE, M. LUISA
Title: Underlying Mechanisms in CADASIL

National Institute of Neurological Disorders and Stroke (NINDS)

Grant No. 1 U01 NS120836 01 PI: WILSON, MICHAEL R
Title: Investigation and Treatment of Undiagnosed Neuroinflammatory Diseases


FY2020 Awards
National Cancer Institute (NCI)

Grant No. 1 U01 CA247439 01 PI: TURAJLIC, SAMRA
Title: Deciphering Clonal Evolution in Hereditary Renal Cell Carcinomas

National Heart, Lung and Blood Institute (NHLBI)

Grant No. 1 U01 HL146188 01A1 PI: WILLIAMS, MARC S.
Title: Collaborative Research to Explore Genetic Variation and Phenotypic Spectrum of Elastin and Related Genes

Grant No. 2 U01 HL131022 04 PI: HENSKE, ELIZABETH P
Title: The Molecular and Genetic Pathogenesis of LAM


FY2019 Awards
National Cancer Institute (NCI)

Grant No. 1 U01 CA236215 01 PI: SLOAN, ANDREW E
Title: Chemoprotection & Immune Remodeling After Hematopoietic Progenitor Cell Gene Therapy for Glioblastoma

Grant No. 1 U01 CA236220 01 PI: GROHAR, PATRICK J
Title: A Collaborative Approach to Analyze and Target the EWS-FLI1 Transcription Factor in Patients with Ewing Sarcoma

Grant No. 1 U01 CA236229 01 PI: LEE, STEPHANIE J
Title: Biologic Correlatives of Chronic GVHD Onset

Grant No. 1 U01 CA236489 01 PI: MCDERMOTT, DAVID
Title: Developing a Translation Pipeline for VHL Mutant Malignancies


FY2018 Awards
National Cancer Institute (NCI)

Grant No. 1 U01 CA224766 01 PI: HEDRICK, CATHERINE C
Title: Protective Role of Nonclassical Monocytes in Immunotherapies for Solid Cancers

National Institute of Allergy and Infectious Diseases (NIAID)

Grant No. 1 U01 AI122269 01A1 PI: BRATTON, DONNA L
Title: Treatment of CGD with the PPAR-gamma agonist, pioglitazone, enhances phagocyte anti-inflammatory
and antimicrobial responses


FY2017 Awards
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Grant No. 1 U01 HD086838 01A1 PI: RADOVICK, SALLY
Title: Genetic Diagnosis of Childhood Growth Disorders

Grant No. 1 U01 HD090845 01A1 PI: ORY, DANIEL S
Title: Intravenous Delivery of 2-hydroxypropyl-Beta-cyclodextrin for Treatment of Niemann-Pick C Disease

National Cancer Institute (NCI)

Grant No. 1 U01 CA202934 01A1 PI: MAHMOOD, UMAR
Title: Optical and Electromagnetic Tracking Guidance for Hepatic Interventions

Grant No. 1 U01 CA202947 01A1 PI: SHARMA, KARUN V
Title: Bench to Bedside: Non-invasive Treatment of Tumors in Children

National Heart, Lung and Blood (NHLBI)

Grant No. 1 U01 HL131014 01A1 PI: SWEITZER, NANCY K
Title: Evaluation of the Safety and Efficacy of Angiotensin 1-7 to Enhance Cognitive Function in Participants
Undergoing Coronary Artery Bypass Graft (CABG) Surgery

National Institute of Allergy and Infectious Diseases (NIAID)

Grant No. 1 U01 AI122275 01A1 PI: GALGIANI, JOHN N
Title: Immuno-Genetic Basis for Human Disseminated Coccidioidomycosis

Grant No. 1 U01 AI129206 01A1 PI: ABATE, ADAM R
Title: Single-Cell Transcriptomic Analysis of HIV-Infected CD4 T Cells in Blood and Lymphoid Tissue Using
PCR-Activated Cell Sorting


FY16 Awards
National Cancer Institute (NCI)

Grant No. 1 U01 CA202943 01 PI: CICHOWSKI, KAREN M
Title: Developing a Translational Pipeline for NF1-Mutant Malignancies

Grant No. 1 U01 CA202939 01 PI: KANTOFF, PHILIP W
Title: Developing Clinical, Immunologic and Radiographic Tools to Measure the Clinical
Effect of Immunotherapy in Biochemically Recurrent Prostate Cancer

National Heart Lung and Blood Institute (NHLBI)

Grant No. 1 U01 HL131019 01 PI: IRUELA-ARISPE, M. LUISA
Title: Underlying Mechanisms of Vascular Disease

Grant No. 1 U01 HL131022 01 PI: HENSKE, ELIZABETH P
Title: The Molecular and Genetic Pathogenesis of LAM

National Institute of Allergy and Infectious Diseases (NIAID)

Grant No. 1 U01 AI122285 01 PI: BLASER, MARTIN J
Title: Microbial, Immune, Metabolic Perturbations by Antibiotics (MIME Study)


FY15 Awards
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Grant No. 1 U01 HD079066-01A1 PI: WOLFE, JOHN H
Title: Choroid Plexus-Directed Gene Therapy for Alpha-Mannosidosis

Grant No. 1 U01 HD082806-01 PI: VANDERVER, ADELINE LUCIE
Title: Antiretroviral Therapy in Aicardi Goutieres Syndrome

National Cancer Institute

Grant No. 1 U01 CA183031 01A1 PI: POMPER, MARTIN G
Title: PSMA Directed Imaging of Prostate Cancer Focus on Androgen Receptor Dynamics

National Heart, Lung and Blood Institute (NHLBI)

Grant No. 1 U01 HL121842 01A1 PI: BYRNE, BARRY J.
Title: Phase II Study of AAV9-GAA Gene Transfer in Pompe Disease

Grant No. 1 U01 HL121841 01A1 PI: IDELL, STEVEN
Title: Single Chain Urokinase Plasminogen Activator (SCUPA) for Treatment of Loculated
Complicated Parapneumonic Effusions and Empyema

National Human Genome Research Institute (NHGRI)

Grant No. 1 U01 HG007587 01 PI: PAGE, DAVID C
Title: Beyond the Reproductive Tract: The Future of Y Chromosome Research

National Institute on Alcohol, Abuse and Alcoholism (NAAA)

Grant No. 1 U01 AA023674 01 PI: FEIN, GEORGE
Title: Cerebellar Structure and Function Studies in Very Early Abstinence

National Institute of Allergy and Infectious Diseases (NIAID)

Grant No. 1 U01 AI115715 01 PI: GREENBERG, HARRY BERNARD
Title: Mucosal and Systemic Immune Responses to Influenza Virus

Grant No. 1 U01 AI115711 01 PI: GRINSPOON, STEVEN K.
Title: Tesamorelin Effects on Liver Fat and Histology in HIV

Grant No. 1 U01 AI115714 01 PI: STOCK, PETER G
Title: Sofosbuvir and Ledipasvir in HIV/HCV Co-infected Pre and Post Liver Transplant


FY14 Awards
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Grant No. 1 U01 HD079065-01 PI: ORY, DANIEL S
Title: A Phase 1 Dose Escalation Study of Vorinostat in Niemann-Pick C1 Disease

Grant No. 1 U01 HD079068-01 PI: JABS, ETHYLIN WANG
Title: Birth Defects: Moebius Syndrome and Related Facial Weakness Disorders

National Cancer Institute

Grant No. 1 U01 CA183030-01 PI: LIU, YANG
Title: Therapeutic Elimination of Stem Cells for Relapsed Pediatric AML

Grant No. 1 U01 CA183027-01 PI: CHINNAIYAN, ARUL M
Title: Integrative Molecular Imaging and Sequencing of Prostate Cancer

Grant No. 1 U01 CA183012-01 PI: ZAIA, JOHN A
Title: Stem Cell Gene Therapy Following R-EPOCH f or Non-Hodgkin Lymphoma in AIDS Patients

National Heart, Lung and Blood Institute (NHLBI)

Grant No. 1 U01 HL121838-01 PI: DEGERTEKIN, F. LEVENT
Title: MRI-safe 3DL Intracardiac Ultrasound Catheter for Cardiovascular Intervention

National Institute of Allergy and Infectious Diseases (NIAID)

Grant No. 1 U01 AI109657-01 PI: MARR, KIEREN A.
Title: Prospective Cohort Study of Cryptococcosis

Grant No. 1 U01 AI109695-01 PI: MORGUN, ANDRIY
Title: Anti-IL-12p40 Treatment of CVID Enteropathy: Gene Expression/Microbiota Analysis

Grant No. 1 U01 AI109697-01 PI: CASANOVA, JEAN-LAURENT
Title: Molecular, Immunological, and Clinical Dissection of STAT1 Hypermorphic Mutations

Grant No. 1 U01 AI109700 PI: HOFFMAN, STEPHEN LEV
Title: PfSPZ Challenge with Chemoprophylaxis: Phase 1 Trial to Assess Liver Stage Drug

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